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Melmet SR Tablets (Metformin)

  • Each tablet contains Metformin 500 mg/1000mg SR.
  • Indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus
  • Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucoseMetformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
  • Administer once daily with the evening meal. Individualize the dose based on effectiveness and tolerability, while not exceeding the maximum recommended daily dose of 2000 mg. If naïve to metformin treatment, initiate with 500 mg daily.
  • Renal impairment. Metabolic acidosis, including diabetic ketoacidosis. Hypersensitivity to metformin hydrochloride.
  • Lactic acidosis: Warn against excessive alcohol intake. Melmet-SR is not recommended in hepatic impairment and is contraindicated in renal impairment. Ensure normal renal function before initiating and at least annually thereafter. Temporarily discontinue in patients undergoing radiologic studies with intravascular administration of iodinated contrast materials or any surgical procedures necessitating restricted intake of food and fluids. Vitamin B12 deficiency: Metformin may lower vitamin B12 levels. Monitor hematologic parameters annually. Macrovascular outcomes: No conclusive evidence of macrovascular risk reduction with Melmet-SR or any other antidiabetic drug.
  • Pregnancy Category B. Safety and effectiveness studies have not been conducted in nursing mothers. Paediatric Use: Safety and effectiveness in children younger than 18 years of age have not been established.
  • Cationic drugs: May reduce metformin elimination. Use with caution in patients who are taking cationic medications eliminated by renal tubular secretion.
  • The most common adverse reactions reported are abnormal stools, hypoglycemia, myalgia, lightheaded, dyspnea, nail disorder, rash, sweating increased, taste disorder, chest discomfort, chills, flu syndrome, flushing and palpitation.
  • Anti-Diabetic agents