Each tablet contains Glimepiride 1 mg/2 mg/4 mg Tablets.
Adjunct to diet or exercise to lower the blood glucose in patients with(type-II) diabetes mellitus whose hyperglycemia cannot be controlled by diet and single agent alone.
The primary mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells. In addition, extra-pancreatic effects may also play a role in the activity of sulphonylureas such as glimepiride.
Once daily with breakfast or first main meal of the day.The starting dose is 1 mg glimepiride per day.
Contraindications:Contraindicated in patients with known hypersensitivity to the drug.Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma.
Glimepiride is a sulfonylurea agent. Caution should be used in patients with G6PD deficiency and a non-sulfonylurea alternative should be considered. All sulfonylurea drugs are capable of producing severe hypoglycaemia. Proper patient selection, dosage, and instructions are important to avoid hypoglycemic episodes
There are no adequate and well-controlled studies in human pregnancy, lactation & children.
The hypoglycaemic action of sulfonylureas may be potentiated by certain drugs, including nonsteroidal anti-inflammatory drugs, clarithromycin, disopyramide, fluoxetine, and quinolones and other drugs that are highly protein bound, such as salicylates, sulfonamides, chloramphenicol, coumarins, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents. A potential interaction between oral miconazole and oral hypoglycaemic agents leads to severe hypoglycaemia.
The adverse effects includehypoglycemia, nausea, diarrhoea, abdominal pain, constipation, vomiting, metallic taste in mouth.
Doctors
Nurses
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