Diapride M1 Forte Tablets (Glimepiride + Metformin)

• Composition :
  Each tablet contains Glimepiride 1 mg + Metformin 1000 mg SR Tablets (in Sustained Release form).
• Indications :
  For patients with type II diabetes mellitus when diet, exercise & single agent does not result in adequate glycemic control
• Pharmacodynamics :
  The primary mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells. In addition, extra-pancreatic effects may also play a role in the activity of sulphonylureas such as glimepiride. Metformin improves glucose tolerance in patients with type-2 diabetes (NIDDM), lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Hence, the combination of glimepiride and metformin sustained-release complements each other and provides better glycemic control in management of type-2 diabetes
• Dosage and administration :
  One tablet once daily with breakfast or first main meal of the day or as directed by physician.
• Contraindications :
  Contraindicated in patients with known hypersensitivity to the drug.Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma
• Precautions and warnings :
  Glimepiride is a sulfonylurea agent, caution should be used in patients with G6PD deficiency and a non-sulfonylurea alternative should be considered. Alcohol is known to potentiate the effect of metformin on lactate metabolism. Patients should be warned against excessive alcohol intake, while receiving metformin
• Use in pregnancy, lactation & pediatrics :
  There are no adequate and well-controlled studies in human pregnancy, lactation & children. This product should only be used in pregnancy if considered essential by the physician.
• Drug interactions :
  The hypoglycaemic action of glimepiride may be potentiated by certain drugs, including nonsteroidal anti-inflammatory drugs, clarithromycin, disopyramide, fluoxetine, and quinolones and other drugs that are highly protein bound, such as salicylates, sulfonamides, chloramphenicol, coumarins, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents. A potential interaction between oral miconazole and oral hypoglycaemic agents leads to severe hypoglycaemia. Certain drugs tend to produce hyperglycemia and may lead to loss of glycemic control produced by metformin. These drugs estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, and isoniazid.
• Adverse reactions :
  The adverse effects include hypoglycemia, nausea, diarrhoea, abdominal pain, constipation, vomiting, metallic taste in mouth.
• Therapy Area :
  Anti-Diabetic agents