Dianorm Tablets (Gliclazide)

• Composition :
  Each tablet contains 80mg of Gliclazide.
• Indications :
  Indicated in the treatment of all types of maturity onset diabetes, diabetes without or with obesity in adults.
• Pharmacodynamics :
  Gliclazide stimulates the release of insulin from pancreatic β-cells, probably by facilitating Ca2+ transport across the β-cell membranes. It causes degranulation of the pancreatic beta-cells, a phenomenon associated with increased rate of insulin secretion.
• Dosage and administration :
  The recommended daily dosage is twice daily with meals.
• Contraindications :
  Known hypersensitivity or allergy to gliclazide, other sulfonylureas, sulphonamides, or to any of the excipients of this product. Type I diabetes,Diabetic pre-coma and coma,Diabetes complicated by ketosis or acidosis,Diabetics undergoing surgery, after severe trauma or during infections,Severe renal or hepatic insufficiency: in these cases the use of insulin is recommended,Treatment with miconazole, pregnancy and lactation,Gliclazide should, where possible, be avoided in porphyria.
• Precautions and warnings :
  The use of gliclazide will not prevent the development of complications peculiar to diabetes mellitus and must be considered as treatment in addition to proper dietary regimen and not as substitute for diet. Treatment of patients with glucose-6-phosphate dehydrogenase (G6PD)-deficiency with sulfonylurea agents can lead to haemolytic anaemia. The metabolism and excretion of gliclazide may be slowed in patients with impaired hepatic and renal function. Hypoglycaemic reactions such as dizziness, lack of energy, drowsiness, headache and sweating have been observed and weakness, nervousness, shakiness and paresthesia have also been reported.
• Use in pregnancy, lactation & pediatrics :
  There are no well controlled studies in pregnancy and lactation. Safety and effectiveness in paediatric patients have not been established.
• Drug interactions :
  Hypoglycaemia may be potentiated when a gliclazide is used concurrently with agents such as: long-actingsulfonamides, tuberculostatics, clarithromycin, salicylates, non-steroidal anti-inflammatory agents, probenecid, beta-blockers. Certain drugs such as diuretics (thiazides, furosemide), corticosteroids oral contraceptives (estrogen plus progestogen) and nicotinic acid may inducehyperglycemia and may lead to loss of control of blood sugar. Gliclazide may potentiate the anticoagulant effect of warfarin and other anticoagulants, dosage adjustments may be necessary.
• Adverse reactions :
  Common adverse effects include hypoglycaemia and gastrointestinal disturbances (including abdominal pain, nausea, vomiting, dyspepsia, diarrhoea, constipation).
• Therapy Area :
  Anti-Diabetic agents